This presentation is an overview of advances in triggered release to biological and external stimuli. Our recent breakthrough bioresponsive material is the first polymeric nanoparticle to release cargo in response to disease-relevant concentrations of H2O2(50 �M) or to activated neutrophils. We have also shown that encapsulation of certain MRI contrast agents in bioresponsive polymers creates an activatable signal.Our investigations of externally triggered release focus on near infrared (NIR), which provides excellent spatiotemporal resolution and relatively deep tissue penetration. We have amplified the response to NIR through creative architectures, including a self-immolative polymer. To enable responsiveness to continuous wave NIR, which is safer and more economical than pulsed lasers, we have taken advantage of water's absorption at 980 nm to induce a phase change, enabling release from common polymers like PLGA with minimal heating, and are incorporating upconverting nanoparticles into our UV-responsive polymer.We are also synthesizing polymers with novel backbone designs to allow rapid depolymerization.

Art of falling apart: Release from nanoparticles on demand

245th National Meeting (2013)

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