Modern continuous flow reactor technologies have proved to significantly expand the range and scope of possible chemistries available to today's synthetic chemist, and allow for rapid testing, optimization, and scaling of chemical sequences. This is reflected in the dramatic increase in the variety and depth of published chemistry over the last few years. However, a limiting factor with these methods relates to inline monitoring as it facilitates and enhances optimization and synchronized control of single and multi-step reactions. Real-time in situ FTIR analysis has already become a standard tool, increasingly utilized to investigate chemistries challenging to analyze using standard offline techniques. This paper will review recent research projects in continuous flow organic synthesis where this powerful non-destructive method technique allowed the formation of products and reactive intermediates to be monitored in real time. Several ongoing investigations in flow will be detailed, including: 1) The Development of a Heterogeneous Catalyst for Highly Stereoselective Mannich Reaction, 2) Safer Control of Vilsmeier-Haack Formylation Transformations, 3) More Efficient Preparation of Aryl Magnesium Reagents, 4) Integrated Preparation and Purification of Aryl Azide Derivatives, 5) Faster Screening and OptiMax of a Modified Knoevenagel Reaction

Recent advances in continuous flow chemistry using real-time in situ FTIR (Fourier Transform Infrared Spectroscopy)

245th National Meeting (2013)

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