The development of a direct anti-Markovnikov hydroamination reaction of unsaturated amines catalyzed by an organic photoredox system will be discussed. This transformation provides access to highly valuable nitrogen heterocycles widely found in biologically active compounds. Currently, very few methods exist to effect anti-Markovnikov hydroaminations and are limited to transition metal catalysts. The development of this novel visible light-activated organocatalyst as well as a discussion of the proposed mechanism and substrate scope of this anti-Markovnikov hydroamination of unsaturated amines will be presented.

Direct anti-Markovnikov hydroamination reactions of unsaturated amines

245th National Meeting (2013)

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