During the healing phase, Epidermal Growth Factor (EGF) is released to help repair damaged tissue; EGF is the protein responsible for stimulating cell growth, proliferation, and differentiation. One approach to dermal tissue engineering would be to present EGF to the surrounding tissue in a way that accelerates the wound healing process. To this end, we have developed a genetically modified version of EGF that can be incorporated covalently into cross-linked polymer hydrogels. Our EGF variant contains a specific sequence designed to cleave the protein from the material scaffold for programmable release upon administration.

Synthesis of genetically engineered epidermal growth factor for controlled release

245th National Meeting (2013)

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