Polymer micelles were made from a diblock copolymer poly(ethylene glycol-b-caprolactone), where the degree of polymerization for the poly(ethylene glycol) block was 45 and either 10 or 20 for the polycaprolactone block. The polycaprolactone in the micelle core was semicrystalline, and it was expected that the crystalline core would trap the cancer drug until the micelle core melted at temperatures above 45�C. 9-(Methylaminomethyl)anthracene was found to give disappointing encapsulation efficiencies of less than 1%. For the diblock copolymer, the best method was to load the drug at high temperatures, about 90�C, when the polycaprolactone core had melted. By loading at high temperatures, the encapsulation efficiency (21%) and loading (10%) of dibucaine was much higher. Thermally-triggered release experiments were carried out a 37�C and at 57�C showed a much high release rate when the temperature was above the melting point of the polycaprolactone core.

Effectof formation conditions on the drug-loading capacity and thermally-triggered release for polymer micelles

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.