In our work, we developed a new approach for non-enzymatic, label-free and convenient protein analysis via pattern recognition. AuNPs decorated with different sequences DNA oligonucleotides form a multi-sensor arrays, which result in colorimetric patterns from the catalytic growth of plasmonic gold nanoparticles (AuNPs). These patterns are then processed with linear discriminant analysis (LDA), which can effectively identify and differentiate six different proteins, as well as the same protein of different concentrations. Importantly, since the whole system has the potential to be minimized into a microarray chip with simple optical readout, it has the potential of being a portable device for diagnosis.

Pattern recognition analysis of proteins using DNA-decorated catalytic gold nanoparticles

245th National Meeting (2013)

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