We have recently developed an efficient iron-catalyzed protocol for the reduction of amides to amines under hydrosilylation conditions. Further studies on this particular transformation revealed that simple Lewis acids, or the use of different bases such as alkoxides, also catalyzed the reduction reaction. Interestingly, depending on the choice of substrate and catalyst used, we can control the reaction to selectively yield either the expected amines, or the less expected enamines as major products, under transition metal free conditions.

Selective catalytic reduction of amides under hydrosilylation conditions

245th National Meeting (2013)

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