Cinchona alkaloids and C2-symmetric binol derived phase transfer catalysts' chiral performance arises from the stereogenic carbon skeleton forcing nitrogen into a chiral environment, yet the diastereomers of salts by virtue of nitrogen epimerisation remain under explored.The synthesis and separation of diastereoisomeric ammonium salts is discussed. By studying diastereoisomers of catalysts in parallel the role of the chirality of the nitrogen atom is probed.

Role of nitrogen's chirality in catalysis

245th National Meeting (2013)

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