We have developed a mild, environment-friendly, and highly efficient asymmetric D-A reaction catalyzed by a chiral magnesium phosphate.This asymmetric D-A reaction provides direct access to six-membered ring spirooxindole, which is a core structure of Gelsemine, as well as other pharmaceutical interesting compounds. A reasonable transition state is also proposed for account for the outcome of the D-A reaction, as well as the crucial function of the Molecular Sieves additive.

Highly enantioselective Diels-Alder reaction catalyzed by chiral phosphate magnesium complex

245th National Meeting (2013)

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