In this presentation, we describe the efficient synthesis of clinprost, a prostacyclin analogue with unique central nervous system binding and neuroprotective activity. The pathway concludes with reactions using three separate transition metal-catalysts___Pd(0), Rh(I), and Ru(II)___to quickly build in molecular complexity, while allowing for late-stage diversification. This synthesis of clinprost is significantly shorter than previously reported routes and, more importantly, enables us to explore the neuroprotective nature of clinprost.

Use of transition metal-catalysts to access a step-economical synthesis of clinprost and clinprost analogs

245th National Meeting (2013)

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