In Skp1, Pro143 is located at the N-terminus of the a-helix followed by five consecutive Glu residues. Small peptides corresponding to the Skp1 sequence are not good substrates for prolyl-4-hydroxylase (P4H1) and a-N-acetylglucosaminyltransferase (Gnt1). This Glu-rich helix is likely to be important for binding at the Gnt1 active site. We are assembling an a-helical mimetic with the expectation that it will be a good substrate for Gnt1 and thereby lead to inhibitor design.

Synthesis of an α-helical mimetic for the 137-151 peptide of Skp1

245th National Meeting (2013)

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