Reaction conditions developed in our group for the iridium catalyzed amination of alcohols, have facilitated the extension of this methodology to more complex substrates. This practical and operationally simple process utilizes a readily available metal catalyst, and reagent grade solvents to afford a mild procedure to convert alcohols into amines. This presentation will discuss the recent developments of this chemistry and highlight the scope and limitations of employing alpha-aminoesters as substrates for amination.

Iridium catalyzed amination of alcohols with alpha-amino esters

245th National Meeting (2013)

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