Alkaloid, (+)-Crispine A was isolated from Cardus crispus in 2002; it is known to possess significant cytotoxic activity especially against SKOV3, KB and Hela human cancer cell lines. For the first time, concise, linear and protecting group-free stereoselective syntheses of both antipodes of Crispine A have been achieved in 6 steps starting from commercially available veratraldehyde. The full synthetic sequence involving Keck allylation and Pummerer rearrangement as crucial transformations will be presented.                                                                         

Concise, stereoselective syntheses of (+)- & (-)-crispine A

245th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.