Absorbable PLGA polymers are widely used in controlled drug delivery and medical device applications. They are key components of absorbable medical devices ranging from sutures, implantables to tissue engineering scaffolds. The synthetic absorbable polyesters are produced by ring opening polymerization of five lactone based monomers namely glycolide, L-lactide, e-caprolactone, p-dioxanone and trimethylenecarbonate (TMC). However, they have limitations in terms of physical and biological properties and the functionality they can offer. To overcome these challenges while still using these five safe and biocompatible lactone monomers, we have developed novel absorbable technology platforms comprised of monomers and absorbable polymers. The absorbable monomers include isocyanantes, biologically active compounds, drug molecules and amino acids. Absorbable polymers include absorbable polyurethanes, polyesters, poly(NSAIDS), poly(amino acids) and poly(esteramides) These polymers will find potential use in drug delivery, tissue engineering, coatings, and implantable medical devices. Key aspects of each absorbable technology platforms will be presented and discussed.

Absorbable polymers beyond PLGA

245th National Meeting (2013)

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