Nitric oxide (NO) is known to be a potent inhibitor of platelet activation and adhesion.  Healthy endothelial cells exhibit a NO flux of 0.5~4�10-10 mol cm-2 min-1.  Materials with a NO flux that is equivalent to this level are expected to have similar anti-thrombotic properties. One approach to mimic this NO flux has been to develop coatings with immobilized catalysts that are capable of locally generating NO from S-nitrosothiols (RSNOs) present in the blood.  Here we investigate the nitric oxide release from SNAP-doped polymers, which can serve as a reservoir of RSNOs and release NO (via thermal and/or photochemical reactions).  The SNAP doped polymers can also be combined with an outer coating containing an immobilized catalyst (e.g. copper nanoparticles) to supplement the endogenous RSNO levels and locally generate NO.  The SNAP-based coatings were examined for improved hemocompatibility in a rabbit model of extracorporeal circulation for activation of platelets and thrombogenicity.

Catalyzed nitric oxide release from <i>S</i>-nitrosoacetylpenicillamine (SNAP)-doped polymers

245th National Meeting (2013)

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Catalyzed nitric oxide release from S-nitrosoacetylpenicillamine (SNAP)-doped polymers