Transition metal mediated decarbonylation reaction has attracted chemists over decades since aldehyde group can control the outcome of a number of useful reactions such as regioselectivity in Diels�Alder reaction and domino oxa�Michael�aldol reaction. An aldehyde can be utilized as in situ CO source for carbonylation reaction, consequently, an external source of hazardous CO gas can be avoided. Recent report established that alka(e)nes are biosynthesized via decarbonylation of fatty aldehydes. Therefore development of a faster and efficient decarbonylation reaction is a highly desirable process to synthetic chemists.  In this context, high cost of rhodium and iridium catalysts prompted us to develop a Pd(OAc)2 catalyzed aldehyde decarbonylation reaction under microwave irradiation. A wide variety of substrates are decarbonylated, without using any exogenous ligand for palladium as well as CO-scavenger. Natural product eulatachromene has been synthesized by using this decarbonylation methodology as a key step starting from easily available materials.

Palladium catalyzed aldehyde decarbonylation reaction under microwave irradiation

245th National Meeting (2013)

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