Regio- and stereoselective alkane dehydrogenation is a difficult challenge in organometallic chemistry. Intermolecular reactions of this type typically produce numerous olefin stereo- and regioisomers. Our use of modified fatty acids has resulted in the first site-selective dehydrogenation of an unactivated acyclic alkyl group. The alkyl group is located on an acylphosphine ligand that is coordinated to a Cp*IrCl2 monomer. Initial investigations into the intramolecular dehydrogenation of the datively bound alkyl ligand will be discussed. Additionally, a mechanistic proposal guided by the isolation of key intermediates will be outlined.

Site-selective dehydrogenation of modified fatty acids

245th National Meeting (2013)

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