Creatine is very well known within the nutrition and fitness industries as a nutritional supplement for increasing muscle size, endurance, and performance based on numerous studies. Creatine salts are becoming popular due to the ability of reducing symptoms of neuromuscular diseases and increased solubility in water compared to creatine monohydrate. Di-creatine citrate, tri-creatine citrate, and creatine pyruvate, salt derivatives of creatine monohydrate, were synthesized using citric and pyruvic acid in combination with creatine monohydrate under various conditions to maximize yields. NMR (Nuclear Magnetic Resonance) was used along with elemental analysis to confirm the chemical formulas of the synthesized compounds. Solubility of each compound was determined and compared to creatine monohydrate to determine the usefulness of the synthesized products.

Synthesis and solubility analysis comparing di-creatine citrate, tri-creatine citrate, and creatine pyruvate to creatine monohydrate

245th National Meeting (2013)

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