Fluorescent nanoparticles offer enormous scientific and technological promise as labels, photon sources and sensors for a range of biotechnological and nanomedicine applications. Many applications require size-controlled, monodisperse, bright nanoparticles that can be specifically conjugated to biological macromolecules, targeted to specific environments, and remotely visualized. As an alternative to single molecule fluorophores and quantum dots, a novel class of multifunctional fluorescent silica-based core-shell nanoparticles referred to as �Cornell dots� or simply �C dots� hold particular promise since they are more biocompatible and are water soluble, and silica chemistry is well established and extremely versatile. The presentation will report on results on C dot synthesis, characterization and optical properties. Various life sciences applications are demonstrated with specific developments towards smaller than 10 nm sized PEGylated labels for nanomedicine, including the first dual-modality (optical/PET) hybrid nanoparticle of its class and properties receiving investigational new drug (IND) FDA approval for first in-human trials in the US.

Cornell dots: Fluorescent core-shell silica nanoparticles to interrogate biological environments

245th National Meeting (2013)

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