Understanding how structural fluctuations, membrane binding and clustering of lipid-modified proteins modulate cell-signaling events is of major biomedical interest. While a great deal has been learned from biophysical, biological and chemical techniques, these techniques do not always have the necessary space/time resolution to address some of the fundamental questions. Physics-based, multi-resolution molecular simulations can play an important role to fill this gap. Using this approach and Ras proteins as model systems, we have investigated the diverse roles of dynamics and membrane-assembly for the biological and biomedical function of lipidated bio-switches. This presentation focuses on our recent results that provide new insights into the role of lipid modification and clustering for membrane remodeling.

Ras dynamics, membrane binding, and assembly

245th National Meeting (2013)

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