The palladium catalyzed intra- and intermolecular C�H arylation is accomplished using inexpensive and readily available tosylates and mesylates as electrophiles. The transformation is efficient for the synthesis of various heterocyclic motifs prevalent in pharmaceutical targets including furans, carbazoles, indoles and lactams. Additionally, a protocol for the one-pot sequential tosylation/arylation or mesylation/arylation of phenol derivatives is presented. Finally, the use of earth abundant and inexpensive nickel catalysts for the intramolecular C�H arylation using C-O electrophiles is described.

Transition metal catalyzed C-H arylation

246th National Meeting (2013)

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