MRI contrasting agents are a key component in the diagnosis of patients. These agents are used to enhance the visibility of internal body structures in magnetic resonance imaging. Currently, the contrast media contains lanthanides to enhance the image.  Our research consists of developing a new delivery system for contrasting agents and to reduce the level of toxicity patients face with current agents. Our focus is to synthesize and study azocorannulene derivatives as a new type of delivery system for contrasting agents. Azocorannulene is analogous to azobenzene; consisting of an azo group anchored by a corannulene group on each end.  Corannulene, a bowl-shaped, polyaromatic hydrocarbon provides an open concave surface for binding while the rim is available for coordination.  The geometric stereochemistry allows azocorannulene to act as a caged type molecule and is idea for encapsulating lanthanides.

Photoswitchable corannulene derivatives

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.