Many biological processes involve electron translocation on long distances. Typically the electron is delivered via electron carriers, small molecules or proteins, either across the water phase or the lipid-protein moiety.  Experimental and computational investigations suggest that the shortest path is not typically utilized; rather longer trajectories are energetically more favorable. Here we investigate the role of electrostatics in two aspects: as a driving force and as a guiding environment. It is demonstrated that in case of large molecular assemblages, as mitochondria complex, the electrostatic field lines provide �electrostatic tunnel� from the electron donor to the electron acceptor sites. The tunnel does not necessary facilitate the electron transport, but provides navigation of the electron carrier throughout the complex lipid-protein moiety.

Revealing the role of electrostatics in guiding long-range electron carriers

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.