End-capped poly(o-phthalaldehyde) [poly(oPA)] is a well-known metastable polymer that has recently attracted significant interest due to its ease of synthesis and rapid depolymerization. Upon end-group cleavage, this kinetically stabilized but thermodynamically unstable (low Tc) polymer undergoes fast depolymerization yielding the low-melting, crystalline o-phthalaldehyde (oPA) monomer in a matter of seconds. The biggest drawback to poly(oPA) is that the polymer is too labile at ambient conditions owing to the sensitive acetal backbone. With poly(oPA) as a lead, related structures that undergo cyclopolymerization were considered as candidates for potentially more stable versions of triggerable polymers. To this end, we prepared novel family of polymers with polyether backbone. Our recent findings on primary structure characterization and triggered degradation of this new class of polymer will be discussed.

Development of novel polymers for encapsulation and controlled release of actives

246th National Meeting (2013)

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