Membrane reorganization during cell signaling is being discovered as a fanscinating phenomenon shared by different cell types. When cells transduce signals, thousands of membrane receptors and signaling molecules reorganize into spatially diverse patterns over many length scales. A hallmark example is the immune cells. It has been recognized that the spatial organization of proteins is directly associated with immune responses, but the underlying mechanisms remain unclear. In the presentation, I will describe how advanced fluorescence imaging, nanotechnology, and cell biology can be combined to understand the protein organization and dynamics in the T cell membrane during signal transduction. I will demonstrate that the combination of multidisciplinary approaches, including single-molecule imaging and tracking, lipid bilayer engineering, and surface fabrication, allow us to elucidate the interconnectivity between physical phenomena and biochemical signaling with high spatiotemporal resolution.

Spatiotemporal imaging of immune cell signaling in membranes

246th National Meeting (2013)

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