Molecular mechanism of metabolism and biological actions of environmental chemicals are important for understanding biodegradability, bioaccumulation, and biological effects on ecosystems. In mammals, P450(CYP) monooxygenases participate in metabolism of foreign chemicals. These P450 genes were engineered in higher plants and examined for biotransformation of environmental chemicals. In mammals, AhR specifically combines with a dioxin-like ligand and induces certain P450 species including CYP1A1 and CYP1A2. AhR genes were engineered in higher plants and tested for monitoring dioxin-like compounds under environmental conditions. Usefulness of these recombinant P450s and AhRs for biotransformation and biomonitoring of environmental chemicals is discussed.

How are recombinant cytochrome P450s and aryl hydrocarbon receptor (AhR) useful for biotransformation and biomonitoring of environmental chemicals?

246th National Meeting (2013)

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