The effects of lipid-like interfaces on vanadium or cobalt complexes include changes in coordination complex structure, stability, and reactivity.  In the following presentation we will discuss these effects and the potentail implications of the changes.  The insulin-enhancing bis(maltolato)oxovanadium(IV) is found to hydrolyze in the presence of the interfaces in contrast to the dipicolinato-cis-dioxovanadium(V) which readily penetrated the interface and remained intact.  The stability of the oxovanadium(V) catecolate 1:1 complex increased dramatically in small reverse micelles, and the origin of the stability was identified to be the decreased rate of complex hydrolysis.  Finally, the reaction of two cobalt complexes the bis(dipicolinato)cobaltate(II) and (ethylenetetracarboxylato)cobaltate(II) with hexacyanoferrate(III) was found to be very different with the former reacting very similarly in aqueous solution and reverse micelles, whereas the latter did not undergo redox chemistry in reverse micelles.  These and other examples all highlight the importance in environment for coordination chemistry, which may be instrumental and explain some of the insulin-enhancing and toxic properties of anti-diabetic vanadium compounds.

Changes in coordination chemistry as a result of environmental influences

246th National Meeting (2013)

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