Metalloenzymes are supramolecular organic-inorganic hybrid materials, which play a vital role in catalysis of biochemical reactions1. In metalloproteins, metal ions are usually coordinated by an imidazole group in histidine residues, a thiolate group in cystein residues, and a carboxylate group on the side chain of aspartate or glutamic acid. Inspired by metalloproteins, we designed and synthesized a de novo peptide amphiphile molecule (Lauryl-VVAGHH-Am) that can coordinate to CuII ions through imidazole moieties of histidine residues. The imidazole units in the peptide molecule coordinate to CuSO4 resulting in a self�assembled nanofiber system. These nanoscale peptide-copper supramolecular systems have been utilized to catalyze Huisgen 1, 3-dipolar cycloaddition of a variety of alkynes and organic azides in aqueous medium at ambient conditions.1. Yoichi M. A. Yamada, Shaheen M. Sarkar, and Yasuhiro Uozumi, J. Am. Chem. Soc. 2012, 134, 9285-9290

Supramolecular peptide - copper complex for click reactions

246th National Meeting (2013)

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