Rodents cause significant damage to agriculture and ecosystems. Rodents also carry vector diseases that can adversely impact public health. Anticoagulant rodenticides are widely used to reduce pest rodent populations and their associated negative impacts. Pest rodents that consume rodenticides may contain rodenticide residues. Non-target avian and mammalian species may be exposed to rodenticides via the consumption of rodenticide exposed target species. A physiologically-based pharmacokinetic (PBPK) model was developed and applied to estimate the magnitude of rodenticide residues in target species exposed to various baiting scenarios. This presentation will demonstrate the utility of PBPK models to identify baiting scenarios that minimize target species rodenticide residues and associated non-target hazards.

Physiologically-based pharmacokinetic model to estimate non-target exposure to rodenticides

246th National Meeting (2013)

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