We use genetically encoded non-natural amino acids as a chemical �handle� to site-specifically couple small molecules and protein components.  Antibody-drug conjugates to a single UAA are homogenous and highly active.  DNA coupled to antibody constant regions enables very sensitive immune-PCR for biodetection applications.  Protein-nucleic acids (PNAs) coupled to different antibody fragments allow basepairing to rapidly form bispecific or higher order heteromultimers, and open unique avenues for protein engineering.

Unnatural amino acids in novel antibody conjugates

246th National Meeting (2013)

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