Polymeric nanomedicine, an emerging field that involves the development of polymeric nanostructures for delivery and diagnostic applications, is expected to alter the landscape of oncology. In current formulation of anticancer polymeric nanostructures, drug molecules are either covalently linked to hydrophilic polymers through conventional coupling chemistry or non-covalently encapsulated into hydrophobic polymeric nanoparticles. In this proceeding we report a new nanoparticle formulation method through drug-initiated, chemo- and regioselective lactide ring-opening polymerization followed by nanoprecipitation. In vitro and in vivo studies will also be reported. Figure 1. <img src='https://acs-archive-assets2.s3.amazonaws.com/239nm/uploads/5337_microchannel_langmuir__test_.jpg' alt='' />

Ring-opening polymerization mediated synthesis of drug-polymer conjugates and nanoconjugates

246th National Meeting (2013)

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