The radioisotope 52Mn has potential to be a useful tool for positron emission tomography (PET)-based molecular imaging in numerous areas of biomedical research. The favorable traits for 52Mn include a long half-life (t1/2=5.6 d) and very low-energy positron emission (E�+,avg=242 keV). For the 52Cr(p,n)52Mn reaction, only one significant cross-section data sets extends above a proton beam energy (Ep) of 11 MeV in the CSISRS/NNDC database. This data set shows a peak at Ep~15 MeV that is broad enough to produce 52Mn with Ep in the range of 8-20 MeV, which is achievable using the cyclotrons found at many biomedical research institutions. Cr metal is too hard and brittle to be hot-rolled into a thin foil suitable for cross-section measurement in a stacked foil bombardment. In this work, we devised a method for fabricating Cr foil for cross-section measurement that was similar to that of Tanaka and Furukawa[1] (1959). As a proof of concept, we electroplated natural Cr onto Cu sheet that had been masked on one side with a vinyl lacquer in an industrial �hard� Cr plating bath. This sample was then placed in concentrated nitric acid, which rapidly dissolved the Cu, leaving only Cr foil. This foil was bombarded with ~15 MeV protons at a very low beam current (~1-2 �A) and allowed to decay for a few days. Gamma spectroscopy confirmed production of 52Mn by signature gamma ray emissions from the foil at 1434, 936, and 744 keV (BR=100.0, 94.5, and 90.0%, respectively). In ongoing work, numerous stacks of Cr foils will be bombarded to yield a complete set of cross-sections from threshold (Ep~6 MeV) to Ep~15 MeV.[1] Tanaka, S.; Furukawa, M. J. Phys. Soc. Jap. 1959,   14, 1269-1275.All data accessed via NNDC.

Targetry and cross-section measurements for the production of <sup>52</sup>Mn using a biomedical cyclotron

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Targetry and cross-section measurements for the production of 52Mn using a biomedical cyclotron

Targetry and cross-section measurements for the production of ⁵²Mn using a biomedical cyclotron