Core-corona assemblies of block copolymers containing various cargo in their cores provide a flexible platform for biomaterials with potential as image enhancement agents in Magnetic Resonance Imaging. One block of the copolymer is designed to interact with the cargo and form the core, while the corona block(s) can be independently tailored to interact with physiological media or particular biological structures. We have prepared block and graft copolymers comprised of nonionic polyethers and polyanionic or functional segments. The ionic components bind to electropositive oxides and ions or cationic therapeutics to comprise the cores of these assemblies, while the nonionic polyethers form the coronas. This lecture will focus on the synthesis and properties of several examples of these materials containing magnetite or manganese cations complexed with carboxylates or phosphonates in light of their molecular and architectural parameters.

Influence of the molecular structure of core-corona nanoparticles on MRI relaxivities and images

246th National Meeting (2013)

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