A facile one-pot strategy to synthesize dye-composited microgels was developed. The rationally selected co-monomers and commercially available dye molecules placed in one pot can be readily fabricated into monodispersed dye-composited microgels via free radical precipitation polymerization in water. With a rational design on functional co-monomers, low cost dye-complexed microgels are capable of continuous glucose detection at near physiological pH via intramolecular B-���N+ bond formation. The glucose sensitive swelling/shrinking of the microgel could shift the p-p stacking of the dye assemblies on the gel network, and thus convert the glucose concentration changes into optical signal changes . The dye-composited microgels with optimal content of functional co-monomers demonstrated high glucose sensitivity and signal reproducibility at physiological pH, which provides a promise for continuous glucose detection.

One-pot strategy to synthesis of dye-embedded microgels for optical detection of glucose at near physiological pH

246th National Meeting (2013)

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