Prior to the 1950's controlled release dosage forms were mostly limited to large size particles and simple mechanical fabrication.  The subsequent development of coacervation and extrusion created the need for better characterization of the particles, especially the determination of a release profile.  Today's methods use DSC, TGA, Zeta potential and others to routinely develop and characterize particles under development and in production.

Development of microencapsulation technologies and subsequent characterization of physical and chemical properties including controlled release

246th National Meeting (2013)

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