We have developed a broadly applicable bioanalysis technology based upon silicon photonics. Arrays of chip-integrated resonant microcavities, each modified with a different target-specific capture agent, can be used to quantitate biomarker levels or monitor biophysical interactions by tracking the shift in resonances that accompany binding.  Key advantages of this technology arise from its genesis in well-established semiconductor processing methodologies, meaning that highly multiplexed sensor arrays can be robustly and cost effectively fabricated on the wafer scale at commercial-scale foundries. This talk will focus on recent developments both in the detection technology and advances in assay design as applied to the detection of panels of protein and nucleic acid targets both for clinical detection applications and fundamental biological discovery.

Silicon photonics meets biology: Multiplexed biomolecular analysis using microring resonator arrays

246th National Meeting (2013)

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