Because of its resistance to classical antibiotics, Pseudomonas aeruginosa has become an important public health problem. P.aeruginosa needs iron, present in low quantity in biological media for its development. To obtain it, P. aeruginosa produces Pyoverdine (Pvd) that is the principal siderophore secreted into the extra-cellular environment where it binds Fe3+ ions.  Then these newly formed pyoverdine-iron complexes are transported back into the cell via specific receptor proteins, namely FpvA. Our objective is to synthesize analogues of Pvd showing a significant siderophore activity and able to antagonize the FpvA receptor or/and carry antibiotics.

Synthesis of pyoverdine analogs with potential antibacterial properties

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.