Glycopolymers play crucial roles in biological communication events due to a dramatic effect of the carbohydrate units on the affinity of recognition biomolecules. Additionally, the precise synthesis of macromolecules with controlled chain length, architecture, monomer sequence provides both an effective and selective binding to the lectins. Therefore, new generation is interested in sequence controlled precision glycopolymer and also there are some very recent examples of sequence controlled glycopolymer synthesis procedures. In this study, the first part includes classical well-defined synthetic glycopolymer structure that were synthesized via RAFT polymerization technique using trimethylsilanyl propargyl methacrylate (TMSMA) and Glycidyl methacrylate (GMA) monomers. In the second part, copolymerization of styrene with pentafluorostyrene (PFS) and poly(ethylene glycol) methyl ether acrylate (PEGA) was performed by the nitroxide-mediated radical polymerization (NMP). Polymerization kinetic of monomers allowed a sufficient control in chain length, architecture, monomer sequence. These obtained glycopolymers were then subject to their potential for biotechnologies applications owing to their recognition of lectins such as targeted drug delivery systems and biocapture analysis as well as therapeutics.Schematic illustration of the glycopolymers in various compositions and architectures.

Synthesis of precision glycopolymers for bioapplications

246th National Meeting (2013)

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