Reactions initiated and/or sustained by mechanical force (mechanochemical reactions) have evolved from a laboratory curiosity into a powerful alternative to conventional synthesis. [Fri�cic Chem. Soc. Rev. 2012  , 41,  3493.] The presentation will focus on catalytic, solvent-free synthesis of porous metal-organic frameworks (MOFs) and metallodrugs (e.g., Pepto-Bismol�) from the simplest precursors. Despite MOFs being one of the 'hottest' areas of materials chemistry, factors controlling their stability and design remain unknown. This presentation will show how mechanochemistry and solid-state chemistry can be used to achieve the low-solvent and energy-efficient synthesis of MOFs, as well as to study factors controlling their stability and structure. The results of the first methodology [Fri�cic et al. Nature Chem. 2013  , 5, 66.] for in situ X-ray diffraction monitoring of reactions during mechanical milling will be presented, demonstrating how real time mechanistic studies lead to a higher understanding of mechanochemistry and improve the ability to design mechanochemical processes. Finally, a new, bioinspired technique of 'accelerated aging' will be presented. Accelerated aging mimics the processes of biological mineralization (mineral neogenesis) to achieve a mild, solvent-free and low-energy route to metal-organic materials, specifically porous MOFs, directy from metal oxide or sulfide precursors.[Fri�cic et al. Nature Chem. 2013  , 5, 66.]

Solid-state chemistry and mechanochemistry for clean, rapid, and efficient synthesis of porous and pharmaceutical metal-organic materials

246th National Meeting (2013)

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