Herein is described a unique automated synthesis lab directed at supplementing the work a medicinal chemist does at the bench.  Traditionally automation technologies have been mainly directed to support parallel library synthesis in a centralized lab under the full direction of a highly-trained and specialized group of chemists.  In contrast, chemical synthesis effort in this lab allows chemists to remotely submit and guide chemical reactions in a highly integrated and automated synthesis lab in a manner that resembles how work is done at their bench - i.e. the pursuit singletons at >= 100 mg scale, in addition to small libraries and multi-step synthetic sequences with complete workflow automation from reagent gathering and mixing to purification and characterization.  This poster describes the layout of the lab, how it functions and is supported, and how it is going about impacting and transforming our approach to doing chemical synthesis in the pursuit of drug discovery.

Remotely-guided automated synthesis lab: A novel paradigm in advancing productivity in drug discovery synthesis

246th National Meeting (2013)

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