Hydrogen sulfide (H2S) is known for its characteristic smell of rotten egg. It has been recently recognized as the third physiological gaseous mediator along with CO and NO involved in several physiological processes including hypertension, inflammation, pain perception, and anticancer effects among others. These findings have fueled the development of a wide range of H2S donors in order to understand the physiological roles of H2S and its therapeutic applications. Our group is interested in the development of a controllable H2S donor. We recently synthesized several phosphorodithioate-based H2S donors and performed tests to evaluate their biological effects. I will present some detailed results of these H2S donors including syntheses, H2S concentration measurements, and biological effects.

Synthesis of phosphorodithioate-based hydrogen sulfide donors and their biological effects

246th National Meeting (2013)

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