The Automated Synthesis Lab (ASL), Lilly's globally accessible platform for organic synthesis, analysis, and isolation, affords a unique opportunity for collaboration between remote research groups.  This poster highlights our partnership with the Broad Institute to create a library of complex macrocycles with potential for further medicinal chemistry exploration via ring closing metathesis (RCM) and Huisgen cycloaddition chemistry.  The library was realized using a Diversity-Oriented Synthesis (DOS) approach for library design, and the ASL, accessed remotely by Broad Institute researchers, for library execution.

Remote synthesis of a DOS library on the automated synthesis lab (ASL)

246th National Meeting (2013)

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