Catalytic chemical methods are a powerful tool for efficiently constructing carbon-carbon and carbon-heteroatom bonds and for providing efficient access to enantioenriched compounds.  The explosion of catalytic methods in the literature in recent years has given rise to large numbers of commercially available catalysts for many types of chemical transformations.  In the Catalysis and Automation Laboratory at Merck, we employ microscale high throughput experimentation techniques to rapidly and rationally screen diverse collections of catalysts, reagents, and reaction conditions.  Herein, we present examples of cross-coupling, asymmetric hydrogenation, and other transformations to showcase the power of high-throughput experimentation for the discovery, development, and optimization of novel chemistry.

Adventures in transition metal catalysis: High throughput experimentation-enabled reaction discovery, development, and optimization

246th National Meeting (2013)

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