A new acaricide, pyriminostrobin, was discovered in our previous work. Based on the conception of introducing fluorine into pyriminostrobin to improve its bio-activity, a series of strobilurin-pyrimidine conjugates were synthesized and bioassayed. Compounds were characterized by 1H NMR, MS and elemental analysis. Highly active compound 7e  was studied by X-ray diffraction. Preliminary bioassays demonstrated that compounds 7e  , 7f  and 7i  exhibited notable control of Tetranychus cinnabarinus (Boisd.) at 1.25 mg L-1. The relationship between structure and acaricidal activity is also reported. Two compounds of particular interest, 7e  and 7i  , exhibited potent acaricidal activity. The acaricidal potencies of these analogs were higher than fluacrypyrim in greenhouse applications, which were more efficacious than pyidaben and were comparable with pyriminostrobin in field trials.

Design, synthesis, and acaricidal activity of strobilurin-pyrimidine conjugates

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.