Radiopharmaceuticals are very powerful diagnostic tools for evaluation a host of medical conditions.  The radioisotope 99mTc is central to many of these compounds.  Understanding and exploiting technetium chemistry can provide insight into the reaction mechanisms and coordination chemistry of these compounds. Ligands are chosen based on their in-situ biological behavior. The coordination chemistry and reaction mechanisms must be efficiently characterized to ensure the reproducibility of the radiopharmaceutical. The current study focuses on Technetium and Rhenium complexes with peptides. These complexes have become increasingly interesting for their use the diagnostic and therapeutic radiopharmaceuticals. The characterization of the complexation of Tc(V), and Rh(V) with the pentapeptide KYCAR (lysyl-tyrosyl-cystyl-alanyl-arginine). Complexes will be characterized by UV-Visible Spectroscopy, NMR, Electrospray Ionization Mass Spectroscopy, Single-crystal XRD, and XAFS, to compare them to current radiopharmaceuticals.  Information on the underlying reactions and coordination will be discussed.

Characterization and crystallization of Re/<sup>99</sup>Tc complexes for radiopharmaceuticals

246th National Meeting (2013)

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.

Characterization and crystallization of Re/99Tc complexes for radiopharmaceuticals

Characterization and crystallization of Re/⁹⁹Tc complexes for radiopharmaceuticals