We have constructed a DNA motor driven by the conversion from a metastable left-handed structure to a more favorable normal right-handed structure, which does not require �toehold� part as most current strand-exchange-based DNA motors do. In this design, the left-handed DNA region contains four domains of half-turn-long, standard B-DNA duplexes, together exhibiting a left-handed profile. This motor can reversibly and continuously transform from free state to stretched state, which was unambiguously confirmed by gel electrophoresis and F�rster resonance energy transfer experiment. The cycling was conducted at room temperature by adding left-handed DNA and its complementary strand alternatively every 30 minute, resulting in higher than 90% completeness each time.

DNA nanomotor powered by a metastable left-handed duplex region

246th National Meeting (2013)

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