Our group harnesses medicinal chemistry design and synthesis to create novel immunogens that elicit antibodies to specific epitopes. In the area of chemical vaccinology, various features of the carrier-linker-hapten construct were explored and optimized to create an immunopharmacotherapeutic anti-nicotine vaccine clinical candidate. Similarly, rational design of synthetic immunogens has enabled multiple monoclonal antibody projects targeting membrane proteins that are difficult to drug using traditional methods such as cell-based immunizations. The synergy between chemologics, chemical biology and molecular biology technologies will be presented, including methods that enable the creation of complex biomolecular architectures necessary for next generation immunogen design.

Chemologics: Using medicinal chemistry to augment monoclonal antibody and vaccine modalities

246th National Meeting (2013)

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