Bisphenol A (BPA) is a prevalent component in polycarbonate plastics that has high production volume in the world. In this study we assessed the growth and locomotion behaviors of the model organism Caenorhabditis elegans (C.elegans) following exposure to BPA. Worms at larvae stage 1 (L1) were exposed to 0.1 and 1 �M of BPA until adulthood, and then transferred to a BPA free plate for behaviors evaluations using a worm tracking system. Several behavioral parameters were used as toxicity endpoints, including smoothed speed, omega bends, and reversals etc. Our results indicated that chronic exposure to BPA is lethal at > 10 �M dosage. The impact of BPA on growth was also evaluated using body length and width. Baseline data has been collected in control and investigations of behavioral effects are ongoing. The behavioral evaluations will help advance the understanding of potential neurological disorders associated with this endocrine disrupting chemical.

Effects of Bisphenol A on growth and locomotion behaviors of <i>C. elegans</i>

246th National Meeting (2013)

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Effects of Bisphenol A on growth and locomotion behaviors of C. elegans