Black tea theaflavins extract (BTE) is rich in antioxidants namely epicatechins and theaflavins. Dietary antioxidants have become popular supplements in prevention of ageing. The present study was to investigate whether BTE could extend the lifespan of Drosophila melanogaster. Results showed the mean lifespan was significantly extended from 51 to 56 days when the fruit flies were given 10 mg/ml BTE. Gene expression of superoxide dismutase (SOD1 and SOD2), catalase (CAT) and methuselah (MTH) was characterized by an increase in young and then a decrease in aged fruit flies. Higher gene expression of SOD1 and CAT was observed in the BTE-treated group than the control flies. However, BTE exerted a minimal effect on the expression of SOD2 and MTH genes. Dietary fat could induce oxidative stress and shorten the maximum lifespan to 15 days, while addition of 10 mg/mL BTE into diet extended it to 28 days. Paraquat and H2O2 challenge tests demonstrated that BTE prolonged the survival time only for Oregon R wild type flies but not for SODn108 or Catn1 mutants. This suggests that the lifespan-prolonging activity of BTE is mediated at least in part through SOD andCAT.

Black tea theaflavins extract extends the lifespan of fruit flies

246th National Meeting (2013)

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