Metal enhanced singlet oxygen generation, from toluidine blue O (TBO) covalently conjugated 6-mercaptohexanoic acid (MHA) coated silver nanoparticles, was observed and quantified. MHA coated silver nanoparticles were synthesized by using sodium borohydride as a reducing agent to react with the mixture of silver nitrate and MHA. The photosensitizers (TBO) were subsequently covalently conjugated with MHA coated silver nanoparticles. The nanoparticles were characterized by UV-Vis absorption spectroscopy and particle size analysis. The singlet oxygen generation was ideally monitored by the 1280nm phosphorescent transmission. Upon 630nm excitation, the sensitizer-nanoparticle conjugates show a significant increase of intensity at 1280nm as compared to the solution when silver nanoparticles were removed by neutralized sodium cyanide solution. The photosensitizer-nanoparticle conjugates were also shown to generate singlet oxygen with enhanced quantum yields as compared to the free TBO. Conjugates of such design, a combination of silver nanoparticles and free photosensitizers, should have good potential as antibacterial agents.

Enhanced singlet oxygen generation from toluidine blue O decorated silver nanoparticles

246th National Meeting (2013)

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